AUTHOR=Guo WenXiao , Li MengZhu 

TITLE=Clinical efficacy of different androgen deprivation therapies for prostate cancer and evaluation based on dynamic-contrast enhanced magnetic resonance imaging

JOURNAL=Acta Biochimica Polonica

VOLUME=71

YEAR=2024

URL=https://www.frontierspartnerships.org/journals/acta-biochimica-polonica/articles/10.3389/abp.2024.12473

DOI=10.3389/abp.2024.12473

ISSN=1734-154X

ABSTRACT=<sec><title>Objective</title><p>To evaluate the clinical efficacy of different androgen deprivation therapies for prostate cancer (PCa) based on dynamic-contrast enhanced magnetic resonance imaging (DCE-MRI).</p></sec><sec><title>Methods</title><p>104 patients with PCa were studied, all of whom were treated with androgen deprivation therapy. The patients were divided into a continuous group (continuous androgen deprivation therapy) and an intermittent group (intermittent androgen deprivation therapy) by random number table method, 52 cases/group. The therapeutic effect and DCE-MRI indices were compared and the relationship between DCE-MRI indices and clinical efficacy and the evaluation value of therapeutic efficacy were analyzed.</p></sec><sec><title>Results</title><p>The objective response rate (ORR) of the intermittent group was higher than that of the continuous group (<italic>p</italic> &lt; 0.05), and there was no significant difference in disease control rate (DCR) between the two groups (<italic>p</italic> &gt; 0.05). After treatment, volume transfer coefficient (K<sup>trans</sup>), reverse transfer constant (K<sub>ep</sub>), volume fraction (Ve), blood volume (BV), and blood flow (BF) in both groups were lowered, and those in the intermittent group were lower than the continuous group (<italic>p</italic> &lt; 0.05). K<sup>trans</sup>, K<sub>ep</sub>, Ve, BF, and BV in the ORR group were lower than those in the non-ORR group (<italic>p</italic> &lt; 0.05). K<sup>trans</sup>, K<sub>ep</sub>, Ve, BF, and BV were correlated with the therapeutic effect of PCa (<italic>p</italic> &lt; 0.05). The AUC value of the combined detection of DCE-MRI indices in evaluating the therapeutic effect of PCa was greater than that of each index alone (<italic>p</italic> &lt; 0.05).</p></sec><sec><title>Conclusion</title><p>Compared with continuous androgen deprivation therapy, intermittent androgen deprivation therapy has better clinical efficacy in the treatment of PCa, and DCE-MRI indices are related to the treatment efficacy of PCa and have an evaluation value.</p></sec>