AUTHOR=Wang Xunqiang , Yang Cece , Zhang Xing , Ye Caiping , Liu Wenping , Wang Chengmin TITLE=Marine natural products: potential agents for depression treatment JOURNAL=Acta Biochimica Polonica VOLUME=71 YEAR=2024 URL=https://www.frontierspartnerships.org/journals/acta-biochimica-polonica/articles/10.3389/abp.2024.12569 DOI=10.3389/abp.2024.12569 ISSN=1734-154X ABSTRACT=

Depression is a common psychiatric disorder. Due to the disadvantages of current clinical drugs, including poor efficacy and unnecessary side effects, research has shifted to novel natural products with minimal or no adverse effects as therapeutic alternatives. The ocean is a vast ecological home, with a wide variety of organisms that can produce a large number of natural products with unique structures, some of which have neuroprotective effects and are a valuable source for the development of new drugs for depression. In this review, we analyzed preclinical and clinical studies of natural products derived from marine organisms with antidepressant potential, including the effects on the pathophysiology of depression, and the underlying mechanisms of these effects. It is expected to provide a reference for the development of new antidepressant drugs.