AUTHOR=Stoyanova Adelina , Galabov Simeon , Galabov Angel S. 

TITLE=Antiviral activity in vitro of double combinations of enteroviral inhibitors

JOURNAL=Acta Virologica

VOLUME=68

YEAR=2024

URL=https://www.frontierspartnerships.org/journals/acta-virologica/articles/10.3389/av.2024.12361

DOI=10.3389/av.2024.12361

ISSN=1336-2305

ABSTRACT=<p>The challenges in combating enteroviruses continue due to their genetic diversity and the rapid development of resistance. Combining antiviral agents offers a promising solution. Our study evaluated the combined effects of pocapavir, a potent capsid-binding inhibitor, with enterovirus-targeting compounds such as pleconaril, 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile (MDL-860), guanidine hydrochloride, oxoglaucine, and 2-α-hydroxybenzyl-benzimidazole (HBB). The combinations tested demonstrated additive to highly synergistic antiviral effects without observed combined cytotoxicity. These results suggest their potential for further research and clinical trials in combating enterovirus infections.</p>