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SPECIAL ISSUE EDITORIAL

Adv. Drug Alcohol Res.
Volume 4 - 2024 | doi: 10.3389/adar.2024.13706
This article is part of the Special Issue 8th Biennial International Drug and Alcohol Research Society (IDARS) Conference 2022 View all 7 articles

Editorial: Drug and alcohol research strategies and therapeutic targeting for substance use disorders

Emmanuel Onaivi Emmanuel Onaivi *
  • William Paterson University, Wayne, United States

The final, formatted version of the article will be published soon.

    priorities, there is need for new research strategies and targets for treating SUDs, as currently available therapies help few that could benefit (2). To address unmet needs in SUD treatment new frontiers in AI beyond CHATGPT with large quantitative AI, and combination with advance sensing may be useful to make new drugs for treating SUDs.This special issue was put together to highlight the research advances and contributions made by some attendees of the 2022, 8 th biennial International Drug and Alcohol Research Society (IDARS) Conference in Nice France. The goal of this special issue was to capture and present research data, reviews and discuss the state of knowledge and future of drug and alcohol addiction that continues to be a global problem. Two research articles provided preclinical data using in-vivo and in-vitro techniques to evaluate the effects of alcohol, and four comprehensive review articles covering diverse molecular, gut microbiome, neuroimmune effects of drugs and alcohol. 2+ -and voltage-gated K + channels of big conductance", investigated the effects of alcohol and pregnenolone (PREG) interaction on cerebral arteries in male and female C57BL/6J mice, to address the consequences in people who may be taking pregnenolone supplements while binge drinking. The study showed that PREG at low concentrations synergized with alcohol in middle cerebral artery (MCA) constriction. Yet this synergism was lost as both PREG and alcohol were probed at higher doses. Other in-vitro electrophysiological data acquisition, and measurements of cerebral artery diameter provided evidence that PREG and alcohol converge on a common pathway to evoke cerebral artery constriction. Furthermore Ca 2+ and voltage-gated K + large conductance channels (BK channel) inhibition by PREG and alcohol involves disruption of allosteric coupling to Ca 2+ -driven gating. As PREG regulates several physiological processes, the study highlights that a combination of PREG and alcohol may affect brain artery function. Of note is that AUDs is occurring in population aged 65 and older, that may be at risk for cerebrovascular ischemic conditions.

    Keywords: alcohol intoxication, nicotine, gut microbiome, epigenetics, neuroimmune interaction

    Received: 26 Aug 2024; Accepted: 24 Dec 2024.

    Copyright: © 2024 Onaivi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Emmanuel Onaivi, William Paterson University, Wayne, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.