AUTHOR=Rosales-Reynoso M. A. , Rosas-Enríquez V. , Saucedo-Sariñana A. M. , Pérez-Coria M. , Gallegos-Arreola M. P. , Salas-González E. , Barros-Núñez P. , Juárez-Vázquez C. I. , Flores-Martínez S. E. , Sánchez-Corona J. 

TITLE=Genotypes and Haplotypes in the AXIN2 and TCF7L2 Genes are Associated With Susceptibility and With Clinicopathological Characteristics in Breast Cancer Patients

JOURNAL=British Journal of Biomedical Science

VOLUME=79

YEAR=2022

URL=https://www.frontierspartnerships.org/journals/british-journal-of-biomedical-science/articles/10.3389/bjbs.2021.10211

DOI=10.3389/bjbs.2021.10211

ISSN=2474-0896

ABSTRACT=<p><bold>Background:</bold> Breast cancer is a multifactorial disease whose genetic susceptibility is related to polymorphic variants of cell proliferation and migration pathways. Variants in <italic>AXIN2</italic> and <italic>TCF7L2</italic> in the Wnt-β catenin pathway have been associated with different types of cancer; however, little is known about its role in breast cancer. This study tests the hypothesis of links between <italic>AXIN2</italic> rs1133683 and rs2240308, and <italic>TCF7L2</italic> rs7903146 and rs12255372 variants in breast cancer.</p><p><bold>Methods:</bold> Peripheral blood samples were obtained from 404 women (202 patients and 202 control females). The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology was used to identify the gene variants.</p><p><bold>Results:</bold> The <italic>AXIN2</italic> rs2240308 (C &gt; T), and <italic>TCF7L2</italic> rs7903146 (C &gt; T) and rs12255372 (G &gt; T) variants were associated with breast cancer and with age, TNM stage, and histologic-molecular subtype (<italic>p</italic> = 0.001). Likewise, the haplotype T-T in the <italic>TCF7L2</italic> gene (rs7903146-rs12253372) was significantly related with breast cancer (OR = 2.66, 95%, CI = 1.64–4.30, <italic>p</italic> = 0.001).</p><p><bold>Conclusion:</bold> Our data show a link between <italic>AXIN2</italic> rs2240308 and <italic>TCF7L2</italic> rs7903146 and rs12255372 variants in breast cancer, and speculate this may be important in pathogenesis.</p>