AUTHOR=Low Hui Ching , Chilian William M. , Ratnam Wickneswari , Karupaiah Tilakavati , Md Noh Mohd Fairulnizal , Mansor Fazliana , Ng Zhi Xiang , Pung Yuh Fen 

TITLE=Changes in Mitochondrial Epigenome in Type 2 Diabetes Mellitus

JOURNAL=British Journal of Biomedical Science

VOLUME=80

YEAR=2023

URL=https://www.frontierspartnerships.org/journals/british-journal-of-biomedical-science/articles/10.3389/bjbs.2023.10884

DOI=10.3389/bjbs.2023.10884

ISSN=2474-0896

ABSTRACT=<p>Type 2 Diabetes Mellitus is a major chronic metabolic disorder in public health. Due to mitochondria’s indispensable role in the body, its dysfunction has been implicated in the development and progression of multiple diseases, including Type 2 Diabetes mellitus. Thus, factors that can regulate mitochondrial function, like mtDNA methylation, are of significant interest in managing T2DM. In this paper, the overview of epigenetics and the mechanism of nuclear and mitochondrial DNA methylation were briefly discussed, followed by other mitochondrial epigenetics. Subsequently, the association between mtDNA methylation with T2DM and the challenges of mtDNA methylation studies were also reviewed. This review will aid in understanding the impact of mtDNA methylation on T2DM and future advancements in T2DM treatment.</p>