AUTHOR=Qiu Yangyang , Qiu Xiaoyan , Chen Yuting , Chen Meiqing , Huang Ling , Lin Xinyu , Wei Yi , Yang Ji , Gao Lujuan 

TITLE=Changes of vitamin D, Th17/Treg related cytokines and their correlations with disease activity in chronic spontaneous urticaria

JOURNAL=Journal of Cutaneous Immunology and Allergy

VOLUME=7

YEAR=2024

URL=https://www.frontierspartnerships.org/journals/journal-of-cutaneous-immunology-and-allergy/articles/10.3389/jcia.2024.13636

DOI=10.3389/jcia.2024.13636

ISSN=2574-4593

ABSTRACT=<sec><title>Aims</title><p>To investigate levels of 25-hydroxyvitamin-D (25HVD), interleukin-17 (IL-17), IL-27, IL-35, and transforming growth factor β1 (TGF-β1) in chronic spontaneous urticaria (CSU) patients and their correlations with disease activity.</p></sec><sec><title>Methods</title><p>An observational, case-control study was conducted. Eighty-one CSU patients and fifty-eight healthy individuals were recruited into two groups. Serum levels of 25HVD, IL-17, IL-27, IL-35, TGF-β1 were determined via enzyme-linked immunosorbent assay (ELISA). Disease activity of CSU was assessed using urticaria activity score (UAS).</p></sec><sec><title>Results</title><p>Serum level of 25HVD was significantly lower in CSU group compared to control group (<italic>P</italic> &lt; 0.001). Serum levels of IL-17 (<italic>P</italic> &lt; 0.001), IL-27 (<italic>P</italic> &lt; 0.001), TGF-β1 (<italic>P</italic> = 0.01) were significantly higher in CSU group than those in control group. In CSU group, the level of 25HVD was negatively associated with IgE (<italic>P</italic> &lt; 0.01) and positively correlated with IL-35 (<italic>P</italic> &lt; 0.01). In addition, serum level of IL-17 was negatively correlated with disease activity among female patients (<italic>P</italic> &lt; 0.05).</p></sec><sec><title>Conclusion</title><p>Deficiency of 25HVD is associated with development of CSU, the underlying mechanism might be related with IL-35. Likewise, IL-17, IL-27, IL-35, and TGF-β1 might also contribute to development of CSU.</p></sec>