AUTHOR=Hasatsri Sukhontha , Jantrapanukorn Bajaree 

TITLE=Film dressings from Thai mango seed kernel extracts versus nanocrystalline silver dressings in antibacterial properties

JOURNAL=Journal of Pharmacy & Pharmaceutical Sciences

VOLUME=27

YEAR=2024

URL=https://www.frontierspartnerships.org/journals/journal-of-pharmacy-pharmaceutical-sciences/articles/10.3389/jpps.2024.12674

DOI=10.3389/jpps.2024.12674

ISSN=1482-1826

ABSTRACT=<p><bold>Introduction:</bold> The extract from the Mango Seed Kernel (MSK) has been documented to exhibit antibacterial activity against Gram-positive and Gram-negative bacteria, including <italic>Staphylococcus aureus</italic> and <italic>Pseudomonas aeruginosa</italic>. This suggests that biomaterials containing MSK extract could be a viable alternative to conventional wound treatments, such as nanocrystalline silver dressings. Despite this potential, there is a notable gap in the literature regarding comparing the antibacterial effectiveness of MSK film dressings with nanocrystalline silver dressings. This study aimed to develop film dressings containing MSK extract and evaluate their antibacterial properties compared to nanocrystalline silver dressings. Additionally, the study aimed to assess other vital physical properties of these dressings critical for effective wound care.</p><p><bold>Materials and methods:</bold> We prepared MSK film dressings from two cultivars of mango from Thailand, ‘Chokanan’ and ‘Namdokmai’. The inhibition-zone method was employed to determine the antibacterial property. The morphology and chemical characterization of the prepared MSK film dressings were examined with scanning electron microscopy (SEM) and Fourier-Transform Infrared Spectroscopy (FTIR), respectively. The absorption of pseudo-wound exudate and water vapor transmission rate (WVTR) of film dressings were evaluated.</p><p><bold>Results:</bold> The results showed that 40% of MSKC film dressing had the highest inhibition zone (20.00 ± 0.00 mm against <italic>S. aureus</italic> and 17.00 ± 1.00 mm against <italic>P. aeruginosa</italic>) and 20%, 30%, and 40% of MSKC and MSKN film dressings had inhibition zones similar to nanocrystalline silver dressing for both <italic>S. aureus</italic> and <italic>P. aeruginosa</italic> (<italic>p</italic> &gt; 0.05). In addition, all concentrations of the MSK film dressings had low absorption capacity, and Chokanan MSK (MSKC) film dressings had a higher WVTR than Namdokmai MSK (MSKN) film dressings.</p><p><bold>Conclusion:</bold> 20%, 30%, and 40% of MSK film dressing is nearly as effective as nanocrystalline silver dressing. Therefore, it has the potential to be an alternative antibacterial dressing and is suitable for wounds with low exudate levels.</p>