AUTHOR=Devanaboyina Monika , Kaur Jasskiran , Whiteley Emma , Lin Leslie , Einloth Katelyn , Morand Susan , Stanbery Laura , Hamouda Danae , Nemunaitis John 

TITLE=NF-κB Signaling in Tumor Pathways Focusing on Breast and Ovarian Cancer

JOURNAL=Oncology Reviews

VOLUME=16

YEAR=2022

URL=https://www.frontierspartnerships.org/journals/oncology-reviews/articles/10.3389/or.2022.10568

DOI=10.3389/or.2022.10568

ISSN=1970-5557

ABSTRACT=<p>Immune disorders and cancer share a common pathway involving NF-κb signaling. Through involvement with GM-CSF, NF-κB can contribute to proliferation and activation of T- and B- cells as well as immune cell migration to sites of inflammation. In breast cancer, this signaling pathway has been linked to resistance with endocrine and chemotherapies. Similarly, in ovarian cancer, NF-κB influences angiogenesis and inflammation pathways. Further, BRCA1 signaling common to both breast and ovarian cancer also has the capability to induce NF-κB activity. Immunotherapy involving NF-κB can also be implemented to combat chemoresistance. The complex signaling pathways of NF-κB can be harnessed for developing cancer therapeutics to promote immunotherapy for improving patient outcomes.</p>