AUTHOR=Hernández-Blanquisett Abraham , Quintero-Carreño Valeria , Martínez-Ávila María Cristina , Porto María , Manzur-Barbur María Carolina , Buendía Emiro TITLE=Metastatic Pancreatic Cancer: Where Are We? JOURNAL=Oncology Reviews VOLUME=17 YEAR=2024 URL=https://www.frontierspartnerships.org/journals/oncology-reviews/articles/10.3389/or.2023.11364 DOI=10.3389/or.2023.11364 ISSN=1970-5557 ABSTRACT=

Pancreatic cancer is one of the most lethal neoplasms worldwide; it is aggressive in nature and has a poor prognosis. The overall survival rate for pancreatic cancer is low. Most patients present non-specific symptoms in the advanced stages, which generally leads to late diagnosis, at which point there is no option for curative surgery. The treatment of metastatic pancreatic cancer includes systemic therapy, in some cases radiotherapy, and more recently, molecular targeted therapies, which can positively impact cancer control and improve quality of life. This review provides an overview of the molecular landscape of pancreatic cancer based on the most recent literature, as well as current treatment options for patients with metastatic pancreatic cancer.