AUTHOR=Mohamed A. , Zeidalkilani J. , Asa S. L. , Trybula M. , Montero Alberto J. TITLE=Management of Neuroendocrine Breast Carcinoma (NEBC): Review of Literature JOURNAL=Oncology Reviews VOLUME=18 YEAR=2024 URL=https://www.frontierspartnerships.org/journals/oncology-reviews/articles/10.3389/or.2024.12114 DOI=10.3389/or.2024.12114 ISSN=1970-5557 ABSTRACT=

Extra pulmonary high-grade poorly differentiated neuroendocrine carcinomas (EP-NECs) are rare tumors that usually arise in the gastrointestinal and genitourinary tracts. Primary neuroendocrine carcinoma of the breast (NEBC) is extremely rare, representing less than 0.1% of all breast cancers and less than 1% of neuroendocrine neoplasms. Consequently, they can be misdiagnosed as other types of breast cancer, however, proper immunohistochemical (IHC) studies can assist with making the correct diagnosis. Management of NEBC can be challenging given the paucity of evidence-based literature and should not routinely follow the therapeutic guidelines of other breast cancers. In this article, we review the current literature regarding the management of NEBC.