AUTHOR=Jung Hee-Yeon , Jeon Yena , Huh Kyu Ha , Park Jae Berm , Kim Myung-Gyu , Lee Sik , Han Seungyeup , Ro Han , Yang Jaeseok , Ahn Curie , Cho Jang-Hee , Park Sun-Hee , Kim Yong-Lim , Kim Chan-Duck 

TITLE=Pretransplant and Posttransplant Alcohol Consumption and Outcomes in Kidney Transplantation: A Prospective Multicenter Cohort Study

JOURNAL=Transplant International

VOLUME=35

YEAR=2022

URL=https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2022.10243

DOI=10.3389/ti.2022.10243

ISSN=1432-2277

ABSTRACT=<p>The impact of pretransplant and posttransplant alcohol consumption on outcomes in kidney transplant recipients (KTRs) is uncertain. Self-reported alcohol consumption was obtained at the time of transplant and 2 years after transplant in a prospective cohort study. Among 907 KTRs, 368 (40.6%) were drinkers at the time of transplant. Compared to non-drinkers, alcohol consumption did not affect the risk of death-censored graft failure (DCGF), biopsy-proven acute rejection (BPAR), cardiovascular events, or all-cause mortality. Compared to persistent non-drinkers, the development of DCGF, BPAR, cardiovascular events, all-cause mortality, or posttransplant diabetes mellitus was not affected by the alcohol consumption pattern (persistent, <italic>de novo</italic>, or stopped drinking) over time. However, <italic>de novo</italic> drinkers had a significantly higher total cholesterol (<italic>p</italic> &lt; 0.001) and low-density lipoprotein cholesterol levels (<italic>p</italic> = 0.005) compared to persistent non-drinkers 5 years after transplant, and had significantly higher total cholesterol levels (<italic>p</italic> = 0.002) compared to the stopped drinking group 7 years after transplant, even after adjusting for the use of lipid-lowering agents, age, sex, and body mass index. Although pretransplant and posttransplant alcohol consumption were not associated with major outcomes in KTRs during the median follow-up of 6.0 years, a new start of alcohol use after KT results in a relatively poor lipid profile.</p><p><bold>Clinical Trial Registration:</bold><ext-link ext-link-type="uri" xlink:href="http://clinicaltrials.gov" xmlns:xlink="http://www.w3.org/1999/xlink">clinicaltrials.gov</ext-link>, identifier NCT02042963.</p>