AUTHOR=Jarrar Faisal , Tennankore Karthik K. , Vinson Amanda J. 

TITLE=Combined Donor-Recipient Obesity and the Risk of Graft Loss After Kidney Transplantation

JOURNAL=Transplant International

VOLUME=35

YEAR=2022

URL=https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2022.10656

DOI=10.3389/ti.2022.10656

ISSN=1432-2277

ABSTRACT=<p><bold>Background:</bold> As the prevalence of obesity increases globally, appreciating the effect of donor and recipient (DR) obesity on graft outcomes is of increasing importance.</p><p><bold>Methods:</bold> In a cohort of adult, kidney transplant recipients (2000–2017) identified using the SRTR, we used Cox proportional hazards models to examine the association between DR obesity pairing (body mass index (BMI) &gt;30 kg/m<sup>2</sup>), and death-censored graft loss (DCGL) or all-cause graft loss, and logistic regression to examine risk of delayed graft function (DGF) and ≤30 days graft loss. We also explored the association of DR weight mismatch (&gt;30 kg, 10-30 kg (D&gt;R; D&lt;R) and &lt;10 kg (D = R)) with each outcome, stratifying by DR obesity pairing.</p><p><bold>Results:</bold> Relative to non-obese DR, obese DR were highest risk for all outcomes (DCGL: HR 1.26, 95% CI 1.22–1.32; all-cause graft loss: HR 1.09, 95% CI 1.06–1.12; DGF: OR 1.98, 95% CI 1.89–2.08; early graft loss: OR 1.34, 95% CI 1.19–1.51). Donor obesity modified the risk of recipient obesity and DCGL [<italic>p</italic> = 0.001] and all-cause graft loss [<italic>p</italic> &lt; 0.001] but not DGF or early graft loss. The known association of DR weight mismatch with DCGL was attenuated when either the donor or recipient was obese.</p><p><bold>Conclusion:</bold> DR obesity status impacts early and late post-transplant outcomes.</p>