AUTHOR=Spaggiari Mario , Petrochenkov Egor , Patel Hiteshi , Di Cocco Pierpaolo , Almario-Alvarez Jorge , Fratti Alberto , Tzvetanov Ivo , Benedetti Enrico 

TITLE=Donor Size Doesn’t Impact En Bloc Kidney Transplant Outcomes: A Single-Center Experience and Review of Literature

JOURNAL=Transplant International

VOLUME=35

YEAR=2022

URL=https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2022.10731

DOI=10.3389/ti.2022.10731

ISSN=1432-2277

ABSTRACT=<p>Few transplant programs use kidneys from donors with body weight (BW)&lt;10 kg due to higher incidence of vascular and urological complications, and DGF. The purpose of this study was to investigate the non-inferiority of pediatric <italic>en bloc</italic> kidneys from donors with BW&lt;10 kg. We performed a single-center retrospective analysis of <italic>en bloc</italic> kidney transplants from pediatric donor cohort (<italic>n</italic> = 46) from 2003 to 2021 and stratified the outcomes by donor BW (small group, donor BW&lt;10 kg, <italic>n</italic> = 30; standard group, donor BW&lt;10 kg, <italic>n</italic> = 16). Graft function, rate of early post-transplant complications, graft and patient survival were analyzed. Complication rates were similar between both groups with 1 case of arterial thrombosis in the smaller group. Overall graft and patient survival rates were similar between the small and the standard group (graft survival—90% vs. 100%, <italic>p</italic> = 0.09; patient survival—96.7 vs. 100%, <italic>p</italic> = 0.48). Serum creatinine at 1, 3, 5 years was no different between groups. Reoperation rate was higher in the small group (23.3% vs. 6.25%, <italic>p</italic> = 0.03). The allograft from small donors could be related to higher reoperation rate in the early post-transplant period, but not associated with lower long-term graft and patient survival.</p>