AUTHOR=Tanaka Sébastien , Tymowski Christian De , Tran-Dinh Alexy , Meilhac Olivier , Lortat-Jacob Brice , Zappella Nathalie , Jean-Baptiste Sylvain , Robert Tiphaine , Goletto Tiphaine , Godet Cendrine , Castier Yves , Mal Hervé , Mordant Pierre , Atchade Enora , Messika Jonathan , Montravers Philippe , the Bichat Lung Transplant Group , Abadie Agnès , Atchade Enora , Ben-rehouma Mouna , Bunel Vincent , Castier Yves , Cerceau Pierre , Ferreira Diego , Frere Gwenn , Genet Lucie , Godet Cendrine , Goletto Tiphaine , Jean-Baptiste Sylvain , Jebrak Gilles , Kantor Elie , Labed Paul , Longrois Dan , Lortat-Jacob Brice , Mal Hervé , Marceau Armelle , Medraoui Chahine , Menonville Charlotte Thibaut de , Messika Jonathan , Mignon Alexandre , Mouren Domitille , Pellenc Quentin , Renard Régis , Roussel Arnaud , Salpin Mathilde , Sandrine Boudinet Léa Copelovici , Savary Alice , Senemaud Jean , Snauwert Aurélie , Stern Jules , Tanaka Sebastien , Tashk Parvine , Tissot Sandrine , Tran-Dinh Alexy , Trigueiros Sabrina , Tymowski Christian de , Weisenburger Gaëlle , Zappella Nathalie TITLE=Low HDL-Cholesterol Concentrations in Lung Transplant Candidates are Strongly Associated With One-Year Mortality After Lung Transplantation JOURNAL=Transplant International VOLUME=36 YEAR=2023 URL=https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2023.10841 DOI=10.3389/ti.2023.10841 ISSN=1432-2277 ABSTRACT=

High-density lipoproteins (HDLs), whose main role is the reverse transport of cholesterol, also have pleiotropic anti-inflammatory, antioxidant, anti-apoptotic and anti-infectious properties. During sepsis, HDL cholesterol (HDL-C) concentration is low, HDL particle functionality is altered, and these modifications are correlated with poor outcomes. Based on the protective effects of HDL, we hypothesized that HDL-C levels could be associated with lung transplantation (LT) outcome. We thus looked for an association between basal HDL-C concentration and one-year mortality after LT. In this single-center prospective study including consecutive LTs from 2015 to 2020, 215 patients were included, essentially pulmonary fibrosis (47%) and chronic obstructive pulmonary disease (COPD) (38%) patients. Mortality rate at one-year was 23%. Basal HDL-C concentration stratified nonsurvivors to survivors at one-year (HDL-C = 1.26 [1.12–1.62] mmol/L vs. HDL-C = 1.55 [1.22–1.97] mmol/L, p = 0.006). Multivariate analysis confirmed that HDL-C concentration during the pretransplant assessment period was the only variable inversely associated with mortality. Moreover, mortality at one-year in patients with HDL-C concentrations ≤1.45 mmol/L was significantly higher (log-rank test, p = 0.00085). In conclusion, low basal HDL-C concentrations in candidates for LT are strongly associated with mortality after LT. To better understand this association, further studies in this field are essential and, in particular, a better characterization of HDL particles seems necessary.