AUTHOR=Riemersma Niels L. , Kremer Daan , Knobbe Tim J. , Gan C. Tji , Nolte Svea , Gomes-Neto António W. , Blokzijl Hans , de Meijer Vincent E. , Damman Kevin , Eisenga Michele F. , Drost Gea , Elting Jan Willem J. , Touw Daan J. , Berger Stefan P. , Bakker Stephan J. L. , van der Stouwe A. M. Madelein , Transplantlines Investigators , Annema Coby , Bakker Stephan J. L. , Berger Stefan P. , Blokzijl Hans , Bodewes Frank A. J. A. , de Boer Marieke T. , Damman Kevin , de Borst Martin H. , Arjan Arjanx , Dijkstra Gerard , Doorenbos Caecilia S. E. , Douwes Rianne M. , Eisenga Michele F. , Erasmus Michele E. , Gan C. Tji , Gomes Neto Antonio W. , Hak Eelko , Hepkema Bouke G. , Frank Klont , Knobbe Tim J. , Kremer Daan , Leuvenink Henri G. D. , Lexmond Willem S. , de Meijer Vincent E. , Niesters Hubert G. M. , Nieuwenhuijs - Moeke Gertrude J. , van Pelt L. Joost , Pol Robert A. , Ranchor Adelita V. , Sanders Jan Stephan F. , Siebelink Marion J. , Slart Riemer J. H. J. A. , Swarte J. Casper , Touw Daan J. , van den Heuvel Marius C. , van Leer-Buter Coretta , van Londen Marco , Verschuuren Erik A. M. , Vos Michel J. , Weersma Rinse K.
TITLE=Tremor, Daily Functioning, and Health-Related Quality of Life in Solid Organ Transplant Recipients
JOURNAL=Transplant International
VOLUME=36
YEAR=2023
URL=https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2023.10951
DOI=10.3389/ti.2023.10951
ISSN=1432-2277
ABSTRACT=Solid organ transplant recipients (SOTR) frequently report tremor. Data concerning tremor-related impairment and its potential impact on health-related quality of life (HRQoL) are lacking. This cross-sectional study assesses impact of tremor on activities of daily living and HRQoL using validated questionnaires among SOTR enrolled in the TransplantLines Biobank and Cohort Study. We included 689 SOTR (38.5% female, mean [±SD] age 58 [±14] years) at median [interquartile range] 3 [1–9] years after transplantation, of which 287 (41.7%) reported mild or severe tremor. In multinomial logistic regression analyses, whole blood tacrolimus trough concentration was an independent determinant of mild tremor (OR per µg/L increase: 1.11, 95% CI: 1.02 to 1.21, p = 0.019). Furthermore, in linear regression analyses, severe tremor was strongly and independently associated with lower physical and mental HRQoL (β = −16.10, 95% CI: −22.23 to −9.98, p < 0.001 and β = −12.68, 95% CI: −18.23 to −7.14, p < 0.001 resp.). SOTR frequently report tremor-related impairment of activities of daily living. Tacrolimus trough concentrations appeared as a main determinant of tremor among SOTR. The strong and independent association of tremor-related impairment with lower HRQoL warrants further studies into the effects of tacrolimus on tremor.
Clinical Trial Registration: ClinicalTrials.gov, Identifier NCT03272841.