AUTHOR=Glorion Matthieu , Sarsam Matthieu , Roux Antoine , Stern Marc , Belousova Natalia , Fessler Julien , Pricopi Ciprian , De Wolf Julien , Picard Clement , Brugière Olivier , De Miranda Sandra , Grenet Dominique , Tachon Guillaume , Cerf Charles , Parquin Francois , Le Guen Morgan , Chapelier Alain , Vallée Alexandre , Sage Edouard TITLE=Results of Lung Transplantation for Cystic Fibrosis With Selected Donors Over 65 Years Old JOURNAL=Transplant International VOLUME=36 YEAR=2023 URL=https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2023.11180 DOI=10.3389/ti.2023.11180 ISSN=1432-2277 ABSTRACT=

Lung transplantation is limited by the shortage of suitable donors. Many programs have begun to use extended criteria donors. Donors over 65 years old are rarely reported, especially for young cystic fibrosis recipients. This monocentric study was conducted for cystic fibrosis recipients from January 2005 to December 2019, comparing two cohorts according to lung donor age (<65 years or ≥65 years). The primary objective was to assess the survival rate at 3 years using a Cox multivariable model. Of the 356 lung recipients, 326 had donors under 65 years, and 30 had donors over 65 years. Donors’ characteristics did not differ significantly in terms of sex, time on mechanical ventilation before retrieval, and partial pressure of arterial oxygen/fraction of inspired oxygen ratio. There were no significant differences in post-operative mechanical ventilation duration and incidence of grade 3 primary graft dysfunction between the two groups. At 1, 3, and 5 years, the percentage of predicted forced expiratory volume in 1 s (p = 0.767) and survival rate did not differ between groups (p = 0.924). The use of lungs from donors over 65 years for cystic fibrosis recipients allows extension of the donor pool without compromising results. Longer follow-up is needed to assess the long-term effects of this practice.