AUTHOR=van Buren Marleen C. , Meinderts Jildau R. , Oudmaijer Christiaan A. J. , de Jong Margriet F. C. , Groen Henk , Royaards Tessa , Maasdam Louise , Tielen Mirjam , Reinders Marlies E. J. , Lely A. Titia , van de Wetering Jacqueline 

TITLE=Long-Term Kidney and Maternal Outcomes After Pregnancy in Living Kidney Donors

JOURNAL=Transplant International

VOLUME=36

YEAR=2023

URL=https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2023.11181

DOI=10.3389/ti.2023.11181

ISSN=1432-2277

ABSTRACT=<p>For counseling it is important to know if pregnancy after Living Kidney Donation (LKD) affects long-term outcomes of the mono-kidney and the mother. Therefore, we performed a retrospective multicenter study in women ≤45 years who donated their kidney between 1981 and 2017. Data was collected via questionnaires and medical records. eGFR of women with post-LKD pregnancies were compared to women with pre-LKD pregnancies or nulliparous. eGFR before and after pregnancy were compared in women with post-LKD pregnancies. Pregnancy outcomes post-LKD were compared with pre-LKD pregnancy outcomes. 234 women (499 pregnancies) were included, of which 20 with pre- and post-LKD pregnancies (68) and 26 with only post-LKD pregnancies (59). Multilevel analysis demonstrated that eGFR was not different between women with and without post-LKD pregnancies (<italic>p</italic> = 0.23). Furthermore, eGFR was not different before and after post-LKD pregnancy (<italic>p</italic> = 0.13). More hypertensive disorders of pregnancy (HDP) occurred in post-LKD pregnancies (<italic>p</italic> = 0.002). Adverse fetal outcomes did not differ. We conclude that, despite a higher incidence of HDP, eGFR was not affected by post-LKD pregnancy. In line with previous studies, we found an increased risk for HDP after LKD without affecting fetal outcome. Therefore, a pregnancy wish alone should not be a reason to exclude women for LKD.</p>