AUTHOR=Bureau Côme , Rafat Cédric , Taupin Jean Luc , Malard Stéphanie , Mesnard Laurent , François Hélène , Petit-Hoang Camille , Ouali Nacera , Hertig Alexandre , Jamme Matthieu , Buob David , Rondeau Eric , Galichon Pierre , Luque Yosu TITLE=Immunoadsorption-Based HLA Desensitization in Patients Awaiting Deceased Donor Kidney Transplantation: An Interventional, Non-Randomised, Single Cohort Study JOURNAL=Transplant International VOLUME=36 YEAR=2023 URL=https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2023.11212 DOI=10.3389/ti.2023.11212 ISSN=1432-2277 ABSTRACT=
Whether immunoadsorption (IADS) as part of desensitization protocols could facilitate deceased donor kidney transplantation (KT) in highly sensitized (HS) patients remains to be proven. We retrospectively analyzed our IADS based desensitization protocol for deceased donor KTs between 2013 and 2018. Fifteen HS patients (age 52 years [40–56]) were included. Waiting time before IADS was 6 years [5–10] and the interval between IADS initiation and KT was 5 months [1–12] for the 14 transplanted patients. Nine patients had prior KT. Calculated panel reactive antibody decreased significantly during the protocol (99.3% [92.5–99.9] vs. 79.4% [56.7–81.9];