AUTHOR=Hsiung Chien-Ya , Chen Hsin-Yu , Wang Shih-Han , Huang Ching-Ying 

TITLE=Unveiling the Incidence and Graft Survival Rate in Kidney Transplant Recipients With De Novo Thrombotic Microangiopathy: A Systematic Review and Meta-Analysis

JOURNAL=Transplant International

VOLUME=37

YEAR=2024

URL=https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2024.12168

DOI=10.3389/ti.2024.12168

ISSN=1432-2277

ABSTRACT=<p><italic>De novo</italic> thrombotic microangiopathy (TMA) is a rare and challenging condition in kidney transplant recipients, with limited research on its incidence and impact on graft survival. This study conducted a systematic review and meta-analysis of 28 cohorts/single-arm studies and 46 case series/reports from database inception to June 2022. In meta-analysis, among 14,410 kidney allograft recipients, <italic>de novo</italic> TMA occurred in 3.20% [95% confidence interval (CI): 1.93–4.77], with systemic and renal-limited TMA rates of 1.38% (95% CI: 06.5–2.39) and 2.80% (95% CI: 1.27–4.91), respectively. The overall graft loss rate of <italic>de novo</italic> TMA was 33.79% (95% CI: 26.14–41.88) in meta-analysis. This study provides valuable insights into the incidence and graft outcomes of <italic>de novo</italic> TMA in kidney transplant recipients.</p>