AUTHOR=Uhl M. , Waeckel T. , Seizilles De Mazancourt E. , Taha F. , Kaulanjan K. , Goujon A. , Beretta A. , Papet J. , Dupuis H. , Panis A. , Peyrottes A. , Lemaire A. , Larose C. , Bettler L. , Pues M. , Joncour C. , Stempfer G. , Ghestem T. , De Sousa P. 

TITLE=Impact of Transplantation Timing on Renal Graft Survival Outcomes and Perioperative Complications

JOURNAL=Transplant International

VOLUME=37

YEAR=2024

URL=https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2024.12202

DOI=10.3389/ti.2024.12202

ISSN=1432-2277

ABSTRACT=<p>Nighttime organ transplantation aims to decrease cold ischemia duration, yet conflicting data exists on its impact on graft function and perioperative complications. This multicenter TRANSPLANT’AFUF study including 2,854 patients, transplanted between 1 January 2011, and 31 December 2022, investigated nighttime kidney transplantation’s impact (8:00 p.m.–8:00 a.m.) versus daytime (8:00 a.m.–8:00 p.m.) on surgical complications and graft survival. Overall, 2043 patients (71.6%) underwent daytime graft, while 811 (28.4%) underwent nighttime graft. No impact was observed of timing of graft surgery on graft survival with a median survival of 98 months and 132 months for daytime and nightime grafting, respectively (<italic>p</italic> = 0.1749). Moreover, no impact was observed on early surgical complications (Clavien I-II = 20.95% for DG and 20.10% for NG; Clavien III-IV-V = 15.42% for DG and 12.94% for NG; <italic>p</italic> = 0.0889) and late complications (&gt;30 days) (Clavien I-II = 6.80% for DG and 5.67% for NG; Clavien III-IV-V = 12.78% for DG and 12.82% for NG; <italic>p</italic> = 0.2444). Noteworthy, we found a significant increase in Maastricht 3 donors’ rates in nighttime transplantation (5.53% DG vs. 21.45% NG; <italic>p</italic> &lt; 0.0001). In conclusion, nighttime kidney transplantation did not impact early/late surgical complications nor graft survival.</p>