AUTHOR=El Hajji Sofia , Lacotte Stéphanie , Moeckli Beat , Cauchy François , Compagnon Philippe , Toso Christian 

TITLE=Transjugular Intrahepatic Portosystemic Shunt Is Associated With Better Waitlist Management of Liver Transplant Candidates With Hepatocellular Carcinoma

JOURNAL=Transplant International

VOLUME=37

YEAR=2024

URL=https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2024.12781

DOI=10.3389/ti.2024.12781

ISSN=1432-2277

ABSTRACT=<p>Transjugular intrahepatic portosystemic shunt (TIPS) reduces portal hypertension complications. Its impact on hepatocellular carcinoma (HCC) remains unclear. We evaluated 42,843 liver transplant candidates with HCC from the Scientific Registry of Transplant Recipients (2002–2022). 4,484 patients with and without TIPS were propensity score-matched 1:3. Analysing wait-list changes in total tumor volume, HCC count, and alpha-fetoprotein levels, and assessing survival from listing and transplantation; TIPS correlated with a decreased nodule count (−0.24 vs. 0.04, <italic>p</italic> = 0.028) over a median wait period of 284 days (IQR 195–493) and better overall survival from listing (95.6% vs. 91.5% at 1 year, <italic>p</italic> &lt; 0.0001). It was not associated with changes in tumor volume (0.28 vs. 0.11 cm³/month, <italic>p</italic> = 0.58) and AFP (14.37 vs. 20.67 ng/mL, <italic>p</italic> = 0.42). Post-transplant survival rates (91.8% vs. 91.7% at 1 year, <italic>p</italic> = 0.25) and HCC recurrence (5.1% vs. 5.9% at 5 years, <italic>p</italic> = 0.14) were similar, with a median follow-up of 4.98 years (IQR 2.5–8.08). While TIPS was associated with a reduced nodule count and improved waitlist survival, it did not significantly impact HCC growth or aggressiveness. These findings suggest potential benefits of TIPS in HCC management, but further studies need to confirm TIPS safety.</p>