AUTHOR=Martinez Eric J. , Pham Phuoc H. , Wang Jesse F. , Stalter Lily N. , Welch Bridget M. , Leverson Glen , Marka Nicholas , Al-Qaoud Talal , Mandelbrot Didier , Parajuli Sandesh , Sollinger Hans W. , Kaufman Dixon B. , Redfield Robert R. , Odorico Jon Scott 

TITLE=Analysis of Rejection, Infection and Surgical Outcomes in Type I Versus Type II Diabetic Recipients After Simultaneous Pancreas-Kidney Transplantation

JOURNAL=Transplant International

VOLUME=37

YEAR=2024

URL=https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2024.13087

DOI=10.3389/ti.2024.13087

ISSN=1432-2277

ABSTRACT=<p>Given the increasing frequency of simultaneous pancreas-kidney transplants performed in recipients with Type II diabetes and CKD, we sought to evaluate possible differences in the rates of allograft rejection, infection, and surgical complications in 298 Type I (T1D) versus 47 Type II (T2D) diabetic recipients of simultaneous pancreas-kidney transplants between 2006-2017. There were no significant differences in patient or graft survival. The risk of biopsy-proven rejection of both grafts was not significantly different between T2D and T1D recipients (HR<sub>pancreas</sub> = 1.04, p = 0.93; HR<sub>kidney</sub> = 0.96; p = 0.93). Rejection-free survival in both grafts were also not different between the two diabetes types (p<sub>pancreas</sub> = 0.57; p<sub>kidney</sub> = 0.41). T2D had a significantly lower incidence of <italic>de novo</italic> DSA at 1 year (21% vs. 39%, p = 0.02). There was no difference in T2D vs. T1D recipients regarding readmissions (HR = 0.77, p = 0.25), infections (HR = 0.77, p = 0.18), major surgical complications (HR = 0.89, p = 0.79) and thrombosis (HR = 0.92, p = 0.90). In conclusion, rejection, infections, and surgical complications after simultaneous pancreas-kidney transplant are not statistically significantly different in T2D compared to T1D recipients.</p>