AUTHOR=Boffini Massimo , Costamagna Andrea , Marro Matteo , Simonato Erika , Cassoni Paola , Bertero Luca , Fanelli Vito , Barbero Cristina , Brazzi Luca , Rinaldi Mauro 

TITLE=Orthostatic Ex-Vivo Lung Perfusion (EVLP): A Proof of Concept

JOURNAL=Transplant International

VOLUME=37

YEAR=2024

URL=https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2024.13178

DOI=10.3389/ti.2024.13178

ISSN=1432-2277

ABSTRACT=<p>The key goal in lung donation remains the improvement of graft preservation with the ultimate objective of increasing the number and quality of lung transplants (LTx). Therefore, in recent years the field of graft preservation focused on improving outcomes related to solid organ regeneration and restoration. In this contest Ex-Vivo Lung Perfusion (EVLP) plays a crucial role with the purpose to increase the donor pool availability transforming marginal and/or declined donor lungs suitable for transplantation. Aim of this proof of concept is to test the safety, suitability and feasibility of a new tilting dome for EVLP designed considering the dorsal lung areas as the “Achilles’ heel” of the EVLP due to a more fluid accumulation than in the supine standard position.</p>