Oxidative Stress and Antioxidants in Health and Disease

Reactive oxygen and nitrogen species are formed in the body under both physiological and induced conditions. Low levels are tolerated by cells and may act as redox messengers in intracellular signaling pathways. However, overproduction affects cell function by damaging structures, preventing their biological activity, and leading to cell death by promoting intrinsic apoptotic pathways. Proteins with enzymatic activity that contain transition metals as cofactors are the most effective defense against them in the organism. Because of their importance, reactive oxygen species are ubiquitous molecules in the organism and thus become useful markers for monitoring the extent of exposure to a variety of substances but also for characterizing normal, physiological conditions. The intake of both natural and synthetically prepared substances is the most acceptable and appropriate way to maintain the body in a normal state by taking advantage of their antioxidant properties and their toxic effects used in the treatment of certain diseases. In vitro and in vivo studies are important to monitor the nature of the action of substances and also point to the importance of monitoring markers of antioxidant status or oxidative stress under physiological conditions as well as in various diseases. The synergism of activities, sites of synthesis, and action of isoforms of antioxidant enzymes are important for the selection, evaluation, and applicability of these markers in humans.

The goal of the Special Issue is to collect all of the available scientific research on natural and synthetic antioxidants and their relation with oxidative stress.

This Special Issue welcomes contributions that improve our understanding of the action of molecules with pro-oxidant and antioxidant activities in health and disease. Potential areas of interest may include, but are not limited to:
● Antioxidant activity of natural compounds.
● Isolation of antioxidants from natural matrixes.
● Analytical methods for the measurement of the antioxidant activity.
● Therapeutical effect of synthetic compounds.
● Effects of endogenous antioxidants in disease.
● Effects of exogenous antioxidants in health and disease.

We encourage the submission of different article types to this collection, especially reviews, mini-reviews, and original research papers.

For authors, please review the journal's information regarding Author Guidelines and Article Processing Charges, or direct any questions to the Editorial Office: abp@frontierspartnerships.org.