Organoids for Transplant Research

Organoids are three-dimensional (3D) structures cultured in vitro aimed to recapitulate the morphology and function of human organs. To date, advances in the fields of stem cell biology and tissue engineering have allowed for the definition of procedures to generate organoids from either human pluripotent stem cells or adult stem cells from healthy individuals or patients. These cutting-edge developments provide a platform for in-depth exploration of human physiology under both healthy and disease conditions in vitro. The potential application of organoids as substitutes for damaged tissues or even whole organs presents a tantalizing prospect in the realm of tissue and organ transplantation. However, such a monumental leap still confronts substantial obstacles. In this Special Issue, we aim to gather experts from the field of organoid technology and transplant research. The convergence of disciplines will be essential to provide conceptual and technical frameworks showing how organoid models can improve our understanding of transplant research and future applications in organ transplantation. Special emphasis will be given to ethical and societal issues in organoid research and ulterior applications in medical transplantation.

The scope of this Special Issue includes, but is not limited to, the following:

· Ethical and societal issues in organoid research and applications;
· Organoids in transplant research;
· Organoids in regenerative medicine;
· Organoids in cell biology;
· Organoids in tissue engineering;
· Organoids in developmental biology


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